Things that interest me this season, though I can't yet vouch personally for the quality either sound interesting or have been recommended by multiple people.
Valkyria Chronicles is awesome. I can tell that the game behind it was done by the same team as the really old Phantasy Star games because the main character is just that awesome, a surprisingly capable female in a culture of moeblobs (I love this word so much), but...
K-On!, despite being moeblob to the extreme, is awesome, as it's basically Lucky Star's moe elements combined with a thicker plot more like Kannagi. Actually the character designs remind me a lot of Miyazaki's films, though admittedly the animation is simpler than Ghibli's work. Understandable, really.
Basquash comes highly recommended, though I still need to see it.
I haven't taken a look at Dragonball Kai or FMA series 2, but I sure want to.
For stuff from last season, Sora o Kakeru Shoujo sure is wacky, anyone who hasn't seen Kannagi needs to, and I am loving Toradora, actually, though you don't need me to tell you that last bit.