Recent and well received visual novel CHAOS;HEAD, by Nitroplus (Blassreiter, etc), is set to receive an anime adaptation, it has been announced in the latest issue of Comic Alive.
Should you not be familiar with the title, it is a gory psychological tale of murder set in realistically depicted Shibuya, with the protagonist a hikikomori. Aside from the quality of story and production, it has attracted attention for the “Delusion Trigger”, where the player can trigger a variety of delusions at various points in the story, giving alternative scenes.
It should be noted that this title is purely a visual novel, with erotic elements downplayed, though plenty of gore is present.
Reading about the game it looks as if some of the more innovative elements of the title will not survive the transition to anime, but presumably the strength lies in the story so this may not be an issue.
For a title only released in April to have already received a manga, and now anime adaptation, is rather striking, so this may be the onset of another strong mixed media franchise.