Sankaku Complex Forums » Anime

221. 

     pikkamakk
     

     Copypasta here, because I'm fucking proud of this!

     Anyway a little tidbit on the history of heroin:
     Heroin was the first designer drug. Morphine was first isolated in 1804, but only got popular in the american civil war. After 30 years of popularity, it got banned in a lot of countries.After that Bayer, using the same method as with aspirin(anhydrous acetic acid+salicylic acid+pressure), made heroin. It was marketed as a non-addictive substitute for morphine, but the molecule was only different from morphine in that the two -OH group(3- and 6-positions) got one-one acetyl substitute for the H atom. Heroin was usually taken orally and with that route of administration, it got quickly metabolized into morphine(O-deacetylation, same as 4-AcO-DMT), so it was basically morphine. When injected/smoked/snorted mainly the acetyl in the 3-position is deacetylated and the result is 6-monoacetylmorphine(6-MAM). The difference between morphine and 6-MAM is that it crosses the blood-brain barrier more quickly, so it gives a quicker, more powerful high.

     Opiates have surprisingly few side-effects, the main ones are very strong addiction, small therapeutic window(ratio of effective dose and lethal dose), high tolerance and the most interesting IMO is the weakening of the immune system(this is why more heroin user have AIDS, than meth users). The last one is because morphine and 6-MAM are actually produced by your own body and they have a role in immunomodulation.

     Pic is a heroin molecule(upper acetyl is the one in the 3-position).

     

     Posted 1 year ago # Quote
222. 

     pilandi
     

     Are you researching stuff because you're going to tell about your drug experiences at some school? "And that children, was the first time I sucked a dick for crack!"

     Posted 1 year ago # Quote
223. 

     pikkamakk
     

     pilandi said:
     Are you researching stuff because you're going to tell about your drug experiences at some school? "And that children, was the first time I sucked a dick for crack!"

     No, I want to work as a researcher in molecular neurology. If you star reading research papers early, you get a head start.

     Posted 1 year ago # Quote
224. 

     pilandi
     

     Oh i get it. In case the cops arrest you, tell them you're doing drugs because you're a researcher on that subject. Does that even work?

     Posted 1 year ago # Quote
225. 

     pikkamakk
     

     pilandi said:
     Oh i get it. In case the cops arrest you, tell them you're doing drugs because you're a researcher on that subject. Does that even work?

     While me liking to get high and being an incurable hedonist are closely intertwined with my interest in neurology, using hallucinogens is actually the "processing information" part, not the "I only get my info from that".
     Also, I don't like opiates and I only used cocaine once and found it mildly entertaining, but not something that worth the price.

     Posted 1 year ago # Quote
226. 

     Uncommon0taku
     

     giascle said:
     Anyone legitimately trying to sound wise in this thread is an idiot.

     does this include yourself as well?

     Posted 1 year ago # Quote
227. 

     giascle
     

     I can't believe I never wrote my life's mantra in here. I'm not sure where it comes from; I think it's an old Indian saying.

     "Everything turns out all right in the end. If it's not all right, it's not the end!"

     This quote has kept me hopeful and stupidly persistent when the world has told me to give up. It always gives me strength when I feel all is lost, and it reminds me if things aren't how I want them, it's either poor timing, or I'm just not working hard enough. If it's timing, then I'm patient until things improve on their own. If it's lack of effort, then I do whatever it takes to prove everyone else wrong. I can't tell you how many times this simple phrase has saved me.

     UncommonOtaku said:

     does this include yourself as well?

     No, because I don't come up with my own quotes. Also I'm always an exception to these kinds of things.

     Posted 1 year ago # Quote
228. 

     Vegio
     

     "Don't stick your penis into crazy".

     Man, do I hate teenagers... uff. It's so hard to find mature people nowadays, huh.

     Posted 1 year ago # Quote
229. 

     brningpyre
     

     "Nothing ever works out; but if you live as hard as you can, you won't miss out on nearly as much."

     "Life is what happens while we make other plans."

     Posted 1 year ago # Quote
230. 

     giascle
     

     It's been kept a secret far too long; I must spread the word of the most brilliant philosopher of our era, and most likely the greatest mind this planet will ever know. Literally within minutes of reading his teachings, you will view the universe in ways you could have never imagined in your wildest fantasies. It is with immense honor I present to you:
     　
     　
     　
     　
     　
     　
     　
     https://twitter.com/#!/Horse_ebooks

     Posted 1 year ago # Quote
231. 

     คภєк๏
     

     giascle said:
     I must spread the word of the most brilliant philosopher of our era, and most likely the greatest mind this planet will ever know.

     You're right, I'll never listen to that rock in my backyard again.

     Posted 1 year ago # Quote
232. 

     giascle
     

     Just remember, my dear cat:

     start amazing

     Posted 1 year ago # Quote
233. 

     Eleriel
     

     A good girlfriend will save you loads of harddrive space.

     Posted 1 year ago # Quote
234. 

     คภєк๏
     

     Eleriel said:
     A good girlfriend will save you loads of harddrive space.

     Unless you have a digital video camera and she's open-minded.

     Posted 1 year ago # Quote
235. 

     Satoko
     

     A terrible, and perhaps manipulative, girlfriend will save you loads of harddrive space.

     Posted 1 year ago # Quote
236. 

     MasterInfamous
     

     A person who says he wants revolution is in reality for the status quo but with different face value.

     Posted 1 year ago # Quote
237. 

     overfiend
     

     You never regret what you buy, half as much as you regret what you failed to buy.

     Although, some people try to avoid this by buying everything.

     

     Attachments

     1. buy-everything.jpg 1 year old

     Posted 1 year ago # Quote
238. 

     Mascarpone
     

     Dun drop da soap!

     Posted 1 year ago # Quote
239. 

     The Superior Triniking
     

     overfiend said:

     

     damn nigga

     Posted 1 year ago # Quote
240. 

     Uncommon0taku
     

     overfiend said:
     You never regret what you buy, half as much as you regret what you failed to buy.

     Although, some people try to avoid this by buying everything.

     that is not everything,... Where are the ball jointed dolfies & the gundam mecha?
     and
     and
     and
     the life sized dutch waifu

     Posted 1 year ago # Quote

Reply »

You must log in to post.